kirazmattson
703 posts
Sep 17, 2025
3:10 AM
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Malegra FXT Plus is a combination medication that contains Sildenafil (used to treat erectile dysfunction, or ED) and Fluoxetine (used to treat premature ejaculation, or PE). It is designed to treat both conditions in men simultaneously. The reason Malegra FXT Plus should be taken only once a day lies in the dosage of the active ingredients and the way these substances interact with the body: 1. High Potency of Active Ingredients: Sildenafil Malegra FXT Plus is a PDE5 inhibitor that increases blood flow to the penis during sexual arousal. Taking more than the prescribed dose can increase the risk of side effects such as headaches, flushing, dizziness, and low blood pressure. Fluoxetine (typically found in doses of 60 mg in Malegra FXT Plus) is a selective serotonin reuptake inhibitor (SSRI) used to delay premature ejaculation by increasing serotonin levels in the brain. Taking it more than once per day can lead to serotonin syndrome, a dangerous condition caused by excess serotonin in the brain, which can cause symptoms like confusion, agitation, increased heart rate, and high blood pressure. 2. Half-Life of the Medications: Both Sildenafil and Fluoxetine have significant half-lives (the time it takes for the body to eliminate half of the dose): Sildenafil has a half-life of about 4 hours, meaning it remains in your body long enough to provide effects for 4 to 6 hours after taking a dose. Taking Sildenafil more than once a day could cause an accumulation of the drug in the body, increasing the likelihood of side effects. Fluoxetine has a much longer half-life (about 4 to 6 days), meaning it stays in your system much longer, and the effects can be prolonged. Overuse of Fluoxetine can cause excessive accumulation of serotonin, leading to potentially severe side effects.
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